Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation
نویسندگان
چکیده
منابع مشابه
The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells.
Activation of Lyn, a Src-related nonreceptor tyrosine kinase, in trophoblast cells is associated with trophoblast giant cell differentiation. The purpose of the present work was to use Lyn as a tool to identify signaling pathways regulating the endocrine differentiation of trophoblast cells. The Src homology 3 domain of Lyn was shown to display differentiation-dependent associations with other ...
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Phosphatidylinositol 3-kinase (PI3K) has been shown to be an important mediator of intracellular signal transduction in mammalian cells. We show here, for the first time, that the blockade of PI3K activity in human fetal undifferentiated cells induced morphological and functional endocrine differentiation. This was associated with an increase in mRNA levels of insulin, glucagon, and somatostati...
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Class-switch recombination (CSR) is essential for humoral immunity. However, the regulation of CSR is not completely understood. Here we demonstrate that phosphatidylinositol 3-kinase (PI3K) actively suppressed the onset and frequency of CSR in primary B cells. Consistently, mice lacking the lipid phosphatase, PTEN, in B cells exhibited a hyper-IgM condition due to impaired CSR, which could be ...
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The signaling pathways that control T cell differentiation have only begun to be elucidated. Using T cell lines, it has been shown that class IA phosphatidylinositol 3-kinase (PI3K), a heterodimer composed of a p85 regulatory and a p110 catalytic subunit, is activated after TCR stimulation. Nonetheless, the contribution of p85/p110 PI3K isoforms in T cell development has not been described. Mic...
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PURPOSE To determine the mechanisms of action of phosphatidylinositol 3-kinase (PI3K) in lens cell differentiation and survival. METHODS Primary quail lens cell cultures were treated at different stages of differentiation with the PI3K inhibitor LY294002, and expression of survival proteins and differentiation markers were determined by immunoblot analysis. The connection between PI3K regulat...
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ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2010
ISSN: 1471-213X
DOI: 10.1186/1471-213x-10-97